Palestinian health officials have said at least 57 people were killed in Israeli bombardments of southern and central areas of Gaza, as fighting continues in several parts of the enclave.
The Palestinian Islamist militant group Hamas has accused Israel of stepping up attacks in Gaza to try to derail efforts by Arab mediators and the United States to reach a ceasefire deal.
Israel says it is trying to root out Hamas fighters.
In Rafah, a southern border city where Israeli forces have been operating since May, five Palestinians were killed in an airstrike on a house, Gaza health officials said.
In nearby Khan Younis, a man, his wife, and two children were killed, they said.
An Israeli airstrike on a car killed at least 17 Palestinians and wounded 26 others in Khan Younis in southern Gaza, the officials said.
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The airstrike hit near a tented area housing displaced families in Attar Street in the humanitarian-designated area of Al-Mawasi, according to the health ministry.
The Israeli military said the strike targeted a senior militant of the Islamic Jihad group, an ally of Hamas.
"We are looking into the reports stating that several civilians were injured as a result of the strike," the military statement said.
Reuters footage showed residents carrying bodies of the dead and wounded on donkey carts and in rickshaws to hospitals.
"The car was targeted, the blood was splashing, and shrapnel hit our tents and martyrs were left on the street. We screamed: "We need an ambulance". We put (the casualties) on carts and rickshaws and the ambulance came after a while," said eyewitness Tahrir Matir, who lives in a tent nearby.
In the historic Nuseirat camp in central Gaza, at least four Palestinians were killed in separate shelling and aerial strikes in central Gaza, medics said. An Israeli airstrike killed four in Sheikh Zayed in northern Gaza, they said.
Hours later, an Israeli air strike on a UN-run school that housed displaced families in the Nuseirat camp killed 23 people and wounded many others, health officials said.
Among those killed was local journalist Mohammad Meshmesh, taking the number of journalists killed in the conflict to 160, the Hamas-run Gaza government media office said.
The Israeli military said in a statement it attacked a group of "terrorists" who had operated from inside the school, after taking steps to mitigate the risk to civilians.
Israel vowed to eradicate Hamas after its militants killed 1,200 people and took over 250 hostage in an attack on southern Israeli communities last 7 October, according to Israeli tallies.
At least 38,713 Palestinians have been killed in Israel's retaliatory offensive since then, Gaza health authorities said in their latest update. Israel also says 326 of its soldiers have been killed in Gaza.
Relatives visited Al-Aqsa Hospital in Deir Al-Balah in central Gaza to say farewell to relatives before funerals.
"We're exhausted, we’re devastated, we are extremely tired, our patience is over," said elderly Palestinian Sahar Abu Emeira. "Whether Hamas or the others (Israel) they need to agree as soon as possible."
Efforts to end the conflict stalled on Saturday after three days of negotiations failed to produce a viable outcome, Egyptian security sources said, and after an Israeli strike targeting Hamas' top military chief, Mohammed Deif.
The attack killed more than 90 people in the Khan Younis area, according to Gaza health authorities.
A Palestinian official close to the negotiations told Reuters Hamas was keen not to be seen as halting the talks despite the stepped-up Israeli attacks.
"Hamas wants the war to end, not at any price. It says it has shown the flexibility needed and is pushing the mediators to get Israel to reciprocate," the official said.
He said Hamas believed Israeli Prime Minister Benjamin Netanyahu was trying to avoid a deal by adding more conditions that restrict the return of displaced people to northern Gaza and to keep control over the Rafah border crossing with Egypt.
US State Department spokesperson Matthew Miller said on Monday that two senior advisers to Netanyahu had said Israel was still committed to reaching a ceasefire.
Israeli strike kills two in south Lebanon
An Israeli air strike killed a Hezbollah fighter and his sister in south Lebanon, the National News Agency (NNA) and the Islamist movement said.
Later, Hezbollah said it fired rockets at northern Israel in response.
Israel's military said it had targeted an arms depot and a military installation belonging to the Iran-backed group.
NNA said another person was seriously wounded when Israeli aircraft hit a house twice, destroying it.
Hezbollah in a statement announced the death of one of its fighters in Bint Jbeil, confirming the NNA's report.
An Israeli military statement said that aircraft "struck a Hezbollah weapons storage facility in the area of Bint Jbeil and a Hezbollah military structure in southern Lebanon" near the border village of Kfar Kila.
The NNA also reported an Israeli strike hitting Kfar Kila.
Hezbollah said it fired dozens of rockets at an Israeli border town of Kiryat Shmona "in response to the aggression of the Israeli enemy including the horrible massacre in Bint Jbeil".
The Israeli military said it shot down about half of the roughly two dozen rockets fired, without mentioning any injuries.
Hezbollah has traded almost daily fire with Israeli forces in support of ally Hamas since 7 October.
The conflict, largely restricted to the border area, has raised fears of all-out conflict between the two parties, who last went to war in the summer of 2006.
In Lebanon, the cross-border violence since October has killed 505 people, mostly fighters but also including 98 civilians, according to an AFP tally.
On the Israeli side, at least 29 people have been killed, the majority of them soldiers, according to the authorities.
